Shrunken Pore Syndrome Is Associated with Renal Function Decline in Female Patients with Kidney Diseases

Table 4

Sensitivity analyses for association between ESRD or severe eGFR decline and SPS by multivariable Cox regression analysis. All the analyses were adjusted for confounders as model 4 in previous tables.

Setting	eGFR decline-all		eGFR decline-male		eGFR decline-female		eGFR decline-MN		ESRD-IgAN
Analyses	HR (95% CI)		HR (95% CI)		HR (95% CI)		HR (95% CI)		HR (95% CI)
Analysis 1	1.87; (0.86~4.06)	0.12	2.21; (0.73~6.72)	0.16	3.71; (1.10~12.50)	0.04	Not convergent	/	0.79; (0.20~3.14)	0.74
Analysis 2	0.19; (0.03~1.07)	0.06	3.93; (0.36~42.95)	0.26	0.02; (0.001~0.52)	0.002	0.21; (0.01~6.23)	0.37	0.88; (0.08~9.94)	0.92
Analysis 3	0.42; (0.06~2.96)	0.38	4.26; (0.37~48.90)	0.24	0.01; (0.000~0.44)	0.02	0.24; (0.01~8.13)	0.43	1.22; (0.10~14.11)	0.88

Analysis 1 used the SPS classification calculated by CKD-EPI equations (SPSEPI); Analysis 2 used continuous eGFRcys/eGFRcr ratio by CAPA-LM equations; Analysis 3 used continuous eGFRcys/eGFRcr ratio by CKD-EPI equations. ESRD: end-stage renal disease; SPS: shrunken pore syndrome; HR: hazard ratio; 95% CI: 95% confidence interval; CKD-EPI: Chronic Kidney Disease Epidemiology Collaboration equations; CAPA: Caucasian Asian Pediatric Adult equation; LM: revised Lund-Malmö equation; IgAN: IgA nephropathy; MN: membranous nephropathy.