|
| Author | Sample size | Site | Stage | Regional failure | Conclusion |
|
| Kowalski and Carvalho [21] (2002) |
SND in none | Oral cavity (100%) | T1 (3%), T2 (45.7%), T3 (28.7%), T4 (22.6%) | — | SND could be done in patients with cN+ at level 1 |
| Andersen et al. [6] (2002) |
SND in 100% | Oral cavity (39.6%), oropharynx (34.9%), larynx (18.9%), hypopharynx (6.6%) | T1 (8.5%), T2 (26.4%), T3 (34.0%), T4 (30.2%) | 4.3% | SND can be done in N+ head and neck cancers without massive adenopathy |
| Santos et al. [7] (2006) |
SND in 28/191 (14.6%) | Oral cavity (14.3%), oropharynx (3.5%), larynx (60.8%), hypopharynx (17.9%), nasopharynx (3.5%) | T1 (7.1%), T2 (7.1%), T3 (25%), T4 (60.8%) | (4/28) 14.2% | SND may be done in selected cases of T1, T2 with N1 |
| Patel et al. [8] (2008) | (232)
SND in 72/232 (31%) | Oral cavity (32.6%), oropharynx (34.6%), larynx (10.2%), hypopharynx (22.4%) | T1-T2 (45.3%), T3-T4% (54.7%) | (19/205) 9.2% | SND can be done in selected N+ cases based on site (poor in hypopharynx), T stage (good in T1 & T2), and N stage (up to N1) |
| Shin et al. [9] (2013) |
SND in 20/92 (21.7%) | Oral cavity (100%) | T1 (13%), T2 (35.8%), T3 (13%), T4 (38%) | (3/20) 15% | SND combined with adjuvant therapy, survival rate comparable to CND in patients under cN2a OSCC |
| Givi et al. [10] (2011) |
SND in all | Oral cavity (71.3%), oropharynx (22.2%), larynx (5%), hypopharynx (1%), nasopharynx (1%) | T1 (14.8%), T2 (44.4%), T3 (9.3%), T4 (18.5%) | (7) 6.5% | SND can be done in selected N+ cases in the setting of MMT. Poor prognosis in oral cavity primaries, >2 neck nodes, and high T stage (T3 and T4) |
| Feng et al. [11] (2014) |
SND in 68/143 (47.5%) | Oral cavity (100%) (tongue & floor of mouth) | T1 (10.5%), T2 (19%), T3 (33%), T4 (37.3%) | (11/65) 16.9% | SND can be done in selected N+ cases |
| Iqbal et al. [12] (2014) |
SND in 100%
cN+ in 61 (27.8%) | Oral cavity (100%) | T1 (44%), T2 (37%), T3 (6%), T4 (9%) | (8/61) 13% | SND can be done in N+ oral cancers |
| Shimura et al. [13] (2019) |
SND in 35/68 (51%) | Oral cavity (100%) | T1(18%), T2(47%)
T3(9%), T4(26%) | (4/35) 11% | SND can be done in N+ limited to levels I and II, for up to 2 lymph nodes that are <3 cm |
| Kakei et al. [23] (2020) |
MND in all | Oral cavity (100%) | T1 (4%), T2 (49%), T3 (22%), T4 (25%) | — | Level V dissection can be excluded |
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