Imaging Characteristics and Prognostic Value of Isolated Pulmonary Metastasis from Colorectal Cancer Demonstrated with18F-FDG PET/CT
Table 2
Image characters of the isolated lung nodules in CRC patients.
Characteristic
Metastasis ( =33) (%)
Primary lung cancer ( =20) (%)
Benign nodule ( =9) (%)
-valuea
-valueb
Maximal diameter of lung lesion (mm)
Median (range)
18 (5-55)
30 (13-60)
14 (9-27)
0.668
0.045
Comparison with the median value
0.021
0.472
≥21.65
14 (42.4)
15 (75.0)
2 (22.2)
<21.65
19 (57.6)
5 (25.0)
7 (77.8)
Lesion location
0.294
0.614
Central
6 (18.2)
7 (35.0)
1 (11.1)
Peripheral
27 (81.8)
13 (65.0)
8 (88.9)
SUVmax of lung lesion
0.165
0.001
Median (range)
4.27 (0.76-16.36)
6.7 (0.80-16.53)
2.4 (0.8-3.84)
18F-FDG uptake
0.862
0.002
Positive
19 (57.6)
12 (60.0)
0 (0.0)
Negative
14 (42.4)
8 (40.0)
9 (100.0)
Metastasis detected on PET/CT
Hilar and/or mediastinal lymph node metastasis
0.269
0.231
+
13 (39.4)
11 (55.0)
1 (11.1)
-
20 (60.6)
9 (45.0)
8 (88.9)
Other site metastasis
0.113
0.112
+
11 (33.3)
2 (10.0)
0 (0.0)
-
22 (66.7)
18 (90.0)
9 (100.0)
CT finding
Polygonal shape
0.035
0.135
+
15 (45.5)
15 (75.0)
1 (11.1)
-
18 (54.5)
5 (25.0)
8 (88.9)
Ill-defined margin
0.025
0.823
+
11 (33.3)
13 (65.0)
4 (44.4)
-
22 (66.7)
7 (35.0)
5 (55.6)
Pleural indentation
0.033
0.862
+
10 (30.3)
12 (60.0)
3 (33.3)
-
23 (69.7)
8 (40.0)
6 (66.7)
Calcification
0.661
0.288
+
3 (9.1)
3 (15.0)
2 (22.2)
-
30 (90.9)
17 (85)
7 (77.8)
Cavity
0.09
0.525
+
2 (6.1)
5 (25.0)
1 (11.1)
-
31 (93.9)
15 (75.0)
8 (88.9)
Air bronchogram
0.024
0.387
+
1 (3.0)
5 (25.0)
1 (11.1)
-
32 (97.0)
15 (75.0)
8 (88.9)
Spiculation
0.031
0.784
+
13 (39.4)
14 (70.0)
4 (44.4)
-
20 (60.6)
6 (30.0)
5 (55.6)
Ground-glass opacity
0.049
0.042
+
0 (0.0)
3 (15.0)
2 (22.2)
-
33 (100)
17 (85.0)
7 (77.8)
SUV: standardized uptake value; PET/CT: positron emission tomography/computed tomography. aTest for difference between the isolated lung metastasis group and the second primary lung cancer group. bTest for difference between the isolated lung metastasis group and the benign nodule group. Statistically significant -values are highlighted in bold.
