Imaging Characteristics and Prognostic Value of Isolated Pulmonary Metastasis from Colorectal Cancer Demonstrated with¹⁸F-FDG PET/CT

Table 4

Univariate and multivariate analysis of factors associated with survival of CRC patients with isolated lung metastasis.

Characteristic	Univariate Analysis HR (95% CI)	p-value	Multivariate Analysis HR (95% CI)	p-value
Metastasis detected on PET/CT
Hilar and/or mediastinal lymph node metastasis	6.107 (1.446-25.79)	0.0138	0.605 (0.039-9.342)	0.719
+
-
Air bronchogram	29460 (40.01-21690000)	0.0022	0.524 (0.011-25.920)	0.745
+
-
Initial TNM stage	680.9 (73.82-6282)	< 0.0001	19.831 (1.061-370.782)	0.046
I-III
IV
Treatment of CRC
Adjuvant chemotherapy	0.2379 (0.06514-0.8688)	0.0298	3.246 (0.248-42.509)	0.37
+
-
CA19-9 (U/ml) level	37.98 (3.169-455.3)	0.0041	10.129 (0.470-218.089)	0.139
≥37
< 37
ITP (months), median
≥3/<3 months	0.04844 (0.01041-0.2254)	0.0001	0.016 (0.00-2.529)	0.110
≥6/<6 months	0.04844 (0.01041-0.2254)	0.0001	0.016 (0.00-2.529)	0.110
≥12/<12 months	0.2373 (0.06782-0.8306)	0.0244	2.877 (0.112-73.697)	0.523

CA19-9: carbohydrate antigen 19-9; ITP: interval to pulmonary nodules; CI: confidence interval; HR: hazards ratio.