Bioactive Vitamin D Attenuates MED28-Mediated Cell Growth and Epithelial–Mesenchymal Transition in Human Colorectal Cancer Cells

<div>Calcitriol suppresses Wnt/<i>β</i>-catenin signaling, cell growth, and epithelial-mesenchymal transition, partially through downregulating MED28 expression, in human colorectal cancer cells. (a) SW480 and HT29 cells were treated with calcitriol (100 nM) for 48 h and subjected to RNA extraction and quantitative real-time polymerase chain reaction as described in Materials and Methods. 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(b) MED28 upregulates Wnt/<i>β</i>-catenin signaling, cell growth, and epithelial-mesenchymal transition, which can be suppressed by calcitriol.</div>

BioMed Research International

fig4

Figure 4

Figure 4: Bioactive Vitamin D Attenuates MED28-Mediated Cell Growth and Epithelial–Mesenchymal Transition in Human Colorectal Cancer Cells 