High-Calcium Microenvironment during the Development of Kidney Calculi Can Promote Phenotypic Transformation of NRK-52E Cells by Inhibiting the Expression of Stromal Interaction Molecule-1

Figure 4

(a and b) Western blot analysis showed that the expression of E-cadherin was significantly decreased and the expression of OPN was significantly increased in the NRK-52E cells after silencing STIM1 protein, which was similar to the NRK-52E cells treated with high-calcium microenvironment. (c) Immunofluorescence analysis further confirmed the above results.

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