Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation

Figure 1

Effect of LBE on skin lesions and IgE levels in DNCB-induced atopic dermatitis mouse model. (a) Skin lesions of the ear in DNCB-induced atopic dermatitis mice. Mice were sensitized by topically applied to both ears with 20 μL of 2% DNCB. After a week, the mice were topically applied to both ears with 20 μL of 1% DNCB for 5 times for a week for 3 weeks. LBE (100 or 300 mg/kg) or DX (5 mg/kg) was orally administered by gavage for five consecutive days per week at the time of 1% DNCB treatment. The image shows ear skin 24 h after the last treatment of DNCB. (b) Ear thickness with DNCB-treated was measured at the time of the 24 h after last of DNCB treatment using a digital ear thickness gauge. (c) Serum IgE levels were measured by ELISA. Serum was collected immediately after sacrifice of DNCB-induced atopic dermatitis mice. compared with DNCB-induced group.

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