Research Article
Prognostic and Immunological Roles of MMP-9 in Pan-Cancer
Table 2
Correlation analysis between MMP-9 and related genes and markers of immune cells of TCGA database (the
values are indicated as
, , and
).
| Description | Gene markers | ACC | KIRC | DLBC | Cor | value | Cor | value | Cor | value |
| CD8+ T cell | CD8A | 0.336 | | 0.111 | | 0.098 | 0.506 | CD8B | 0.363 | | 0.095 | | 0.021 | 0.886 |
| T cell (general) | CD3D | 0.405 | | 0.192 | | 0.130 | 0.379 | CD3E | 0.371 | | 0.201 | | 0.098 | 0.510 | CD2 | 0.342 | | 0.182 | | 0.123 | 0.403 |
| B cell | CD19 | −0.040 | 0.723 | 0.306 | | 0.081 | 0.583 | CD79A | 0.050 | 0.664 | 0.316 | | 0.066 | 0.654 |
| Monocyte | CD86 | 0.292 | | 0.248 | | 0.101 | 0.493 | CSF1R | 0.220 | 0.051 | 0.255 | | 0.231 | 0.114 |
| TAM | CCL2 | 0.071 | 0.537 | −0.071 | 0.102 | 0.237 | 0.105 | CD68 | 0.254 | 0.024 | 0.255 | | 0.343 | 0.017 | IL-10 | 0.545 | | 0.302 | | 0.360 | 0.012 |
| M1 macrophage | NOS2 | 0.408 | | −0.063 | 0.148 | 0.176 | 0.233 | IRF5 | 0.169 | 0.137 | 0.062 | 0.153 | 0.049 | 0.739 | PTGS2 | 0.505 | | 0.228 | | 0.151 | 0.305 |
| M2 macrophage | CD163 | 0.400 | | 0.305 | | 0.176 | 0.232 | VSIG4 | 0.350 | | 0.342 | | 0.120 | 0.418 | MS4A4A | 0.375 | | 0.302 | | 0.340 | 0.018 |
| Neutrophils | CEACAM8 (CD66b) | 0.187 | 0.098 | 0.004 | 0.925 | 0.150 | 0.310 | ITGAM (CD11b) | 0.290 | | 0.202 | | 0.487 | 0.000 |
| Natural killer cell | KIR2DL1 | 0.101 | 0.376 | −0.029 | 0.503 | 0.047 | 0.753 | KIR2DL3 | 0.034 | 0.765 | −0.060 | 0.166 | 0.063 | 0.671 | KIR2DL4 | 0.318 | | 0.085 | | 0.106 | 0.473 | KIR3DL1 | 0.142 | 0.211 | −0.111 | | 0.141 | 0.338 | KIR3DL2 | −0.202 | 0.074 | −0.014 | 0.754 | 0.103 | 0.485 | KIR3DL3 | 0.159 | 0.161 | 0.026 | 0.541 | 0.043 | 0.771 | KIR2DS4 | 0.145 | 0.203 | 0.014 | 0.755 | 0.065 | 0.658 |
| Dendritic cell | HLA-DPB1 | 0.161 | 0.157 | 0.147 | | 0.196 | 0.182 | HLA-DQB1 | 0.117 | 0.306 | 0.037 | 0.391 | 0.128 | 0.384 | HLA-DRA | 0.137 | 0.227 | 0.143 | | 0.120 | 0.418 | HLA-DPA1 | 0.075 | 0.510 | 0.118 | | 0.131 | 0.376 | NRP1 (BDCA-4) | 0.239 | 0.034 | 0.044 | 0.305 | 0.139 | 0.348 | CD1C (BDCA-1) | 0.011 | 0.924 | 0.090 | | 0.009 | 0.952 | ITGAX (CD11c) | 0.340 | | 0.271 | | 0.536 | 0.000 |
| Th1 | TBX21 | 0.434 | | 0.053 | 0.224 | 0.076 | 0.610 | STAT4 | 0.463 | | 0.178 | | 0.067 | 0.653 | STAT1 | 0.301 | | 0.062 | 0.154 | 0.096 | 0.517 | IFNG (TNF-γ) | 0.397 | | 0.098 | | 0.137 | 0.354 | TNF (TNF-α) | 0.070 | 0.541 | 0.069 | 0.110 | 0.204 | 0.165 |
| Th2 | GATA3 | 0.026 | 0.820 | 0.044 | 0.308 | 0.134 | 0.363 | STAT6 | −0.206 | 0.069 | −0.054 | 0.216 | 0.365 | 0.011 | STAT5A | 0.198 | 0.080 | 0.193 | | 0.117 | 0.429 | IL-13 | 0.035 | 0.762 | 0.044 | 0.311 | 0.099 | 0.504 |
| Tfh | BCL6 | 0.087 | 0.445 | 0.191 | | 0.100 | 0.498 | IL-21 | 0.000 | 1.000 | 0.165 | | 0.061 | 0.680 |
| Th17 | STAT3 | 0.200 | 0.078 | 0.087 | | 0.371 | 0.009 | IL-17A | 0.000 | 1.000 | 0.065 | 0.135 | 0.023 | 0.879 |
| Treg | FOXP3 | 0.162 | 0.153 | 0.385 | | 0.196 | 0.181 | CCR8 | 0.015 | 0.899 | 0.250 | | 0.181 | 0.217 | STAT5B | 0.017 | 0.880 | −0.193 | | 0.229 | 0.118 |
| T cell exhaustion | TGFB1 | 0.522 | | 0.411 | | 0.090 | 0.542 | PDCD1 (PD-1) | 0.399 | | 0.141 | | 0.007 | 0.961 | CTLA4 | 0.392 | | 0.155 | | 0.177 | 0.230 | LAG3 | 0.412 | | 0.169 | | 0.026 | 0.862 | HAVCR2 (TAM-3) | 0.299 | | 0.040 | 0.358 | 0.054 | 0.715 | GZMB | 0.551 | | 0.140 | | 0.163 | 0.269 |
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