Genetic Association of ERCC6 rs2228526 Polymorphism with the Risk of Cancer: Evidence from a Meta-Analysis

Table 1

Association between individual study characteristics and ERCC6 rs2228526 polymorphism.

Reference	Year	Area	Ethnicity	Cancer style	Source of control	Cases	Controls	Cases			Controls			HWE (control)	Genotyping
								AA	AG	GG	AA	AG	GG		Method
Chang et al.	2009	China	Asian	Bladder cancer	HB	288	288	248	36	4	242	43	3	0.443	PCR-RFLP
Chiu et al.	2008	China	Asian	Oral cancer	HB	292	290	259	30	3	243	44	3	0.455	PCR-RFLP
Huang et al.	2006	America	Mix	Colorectal adenoma	HB	646	657	405	211	30	410	224	23	0.284	National Cancer Institute Core Genotyping Facility
Ma et al.	2009	China	Asian	Lung cancer	PB	500	504	429	69	2	451	51	2	0.653	Illumina SNP genotyping BeadLab platform
Rajaraman et al.	2008	America	Mix	Breast cancer	HB	790	1070	510	241	39	704	312	54	0.015	TaqMan
Ramaniuk et al.	2014	Belarus	Caucasian	Bladder cancer	PB	336	369	167	145	24	187	152	30	1.000	PCR-RFLP
Zhang et al.	2014	China	Asian	Prostate cancer	HB	229	238	90	105	34	113	103	22	0.880	MassARRAY platform
Zheng et al.	2010	America	Caucasian	Lung cancer	HB and PB	161	281	97	55	9	170	95	16	0.744	TaqMan
Zheng et al.	2010	America	African Americans	Lung cancer	HB and PB	59	175	43	14	2	130	40	5	0.528	TaqMan
Ibarrola-Villava et al.	2011	Spanish	Caucasian	Malignant melanoma	HB	684	406	339	215	30	253	137	16	0.763	TaqMan
Pan et al.	2009	America	Caucasian	Esophageal cancer	HB	382	452	235	125	22	291	147	14	0.452	TaqMan
Wu et al.	2006	America	Caucasian	Bladder cancer	HB	605	595	371	204	30	392	182	21	1.000	TaqMan
Yang et al.	2013	China	Asian	Prostate cancer	HB	229	238	90	105	34	113	103	22	0.881	PCR-RFLP
Savina et al.	2017	Belarus	Caucasian	Bladder cancer	PB	419	354	207	182	30	176	148	30	1.000	PCR-RFLP
Han et al.	2008	America	Mix	Breast cancer	PB	236	470	134	89	13	288	161	21		Illumina high-multiplex BeadArray genotyping system

Abbreviations: HB = hospital based; PB = population based; HWE = Hardy–Weinberg equilibrium; F = fixed-effects mode; R = random-effects model.