Genetic Association of ERCC6 rs2228526 Polymorphism with the Risk of Cancer: Evidence from a Meta-Analysis
Table 2
Main results of pooled ORs in the meta-analysis.
Study groups
No. of study
Sample size (cases/controls)
G vs. A
GG vs. AA
GA vs. AA
GA + GG vs. AA
GG vs. GA + AA
OR [95% CI]
(%)
Model
OR [95% CI]
(%)
Model
OR [95% CI]
(%)
Model
OR [95% CI]
(%)
Model
OR [95% CI]
(%)
Model
Overall
15
5856/6837
1.10 [1.03, 1.17]
11.7
F
1.27 [1.07, 1.51]
0
F
1.08 [1.00, 1.17]
0
F
1.10 [1.02, 1.19]
0
F
1.22 [1.03, 1.45]
0
F
Cancer style
Bladder cancer
4
1648/1606
1.05 [0.93, 1.18]
0
F
1.05 [0.77, 1.44]
0
F
1.08 [0.92, 1.25]
0
F
1.07 [0.93, 1.24]
0
F
1.01 [0.74, 1.38]
0
F
Lung caner
3
720/960
1.14 [0.91, 1.43]
0
F
1.00 [0.55, 1.83]
0
F
1.19 [0.92, 1.55]
0
F
1.18 [0.92, 1.52]
0
F
1.00 [0.55, 1.82]
0
F
Prostate cancer
2
458/476
1.361.12, 1.65]
0
F
1.07 [0.74, 1.55]
0
F
1.10 [0.92, 1.31]
0
F
1.09 [0.93, 1.29]
0
F
1.02 [0.50, 2.05]
0
F
Breast cancer
2
1026/1540
1.07 [0.93, 1.23]
0
F
1.94 [1.27, 2.97]
0
F
1.28 [0.97, 1.68]
0
F
1.40 [1.08, 1.81]
0
F
1.71 [1.14, 2.56]
0
F
Other cancer
4
2004/1805
1.08 [0.96, 1.21]
41.5
F
1.46 [1.03, 2.07]
0
F
1.00 [0.87, 1.16]
36.4
F
1.04 [0.91, 1.20]
41.7
F
1.44 [1.02, 2.04]
0
F
Ethnicity
Asian
5
1538/1558
1.14 [0.90, 1.45]
59
R
1.77 [1.20, 2.61]
0
F
1.07 [0.81, 1.42]
55.3
R
1.12 [0.84 1.50]
60.4
R
1.61 [1.11, 2.23]
0
F
Caucasian
6
2587/2457
1.10 [1.00, 1.21]
0
F
1.19 [0.92, 1.53]
8
F
1.10 [0.98, 1.24]
0
F
1.12 [1.00, 1.25]
0
F
1.14 [0.89, 1.46]
7.3
F
African Americans
1
59/175
1.08 [0.60, 1.94]
—
—
1.21 [0.23, 6.46]
—
—
1.06 [0.53, 2.13]
—
—
1.07 [0.55, 2.09]
—
—
1.19 [0.23, 6,32]
0
F
Mix
3
1672/2197
1.06 [0.94, 1.18]
0
F
1.14 [0.84, 1.55]
0
F
1.04 [0.91, 1.20]
0
F
1.03 [0.92, 1.21]
0
F
1.12 [0.83, 1.52]
Source of controls
HB
9
4145/4234
1.16 [1.06, 1.27]
31.6
F
1.49 [1.17, 1.90]
0
F
1.12 [1.00, 1.25]
16.1
F
1.16 [1.04, 1.29]
26.5
F
1.40 [1.11, 1.77]
0
F
PB
4
1491/1697
1.04 [0.94, 1.15]
0
F
1.06 [0.81, 1.39]
0
F
1.04 [0.92, 1.18]
0
F
1.05 [0.93, 1.18]
0
F
1.14 [0.80, 1.36]
0
F
HB, PB
2
220/456
1.02 [0.77, 1.36]
0
F
1.03 [0.48, 2.20]
0
F
1.03 [0.72, 1.47]
0
F
1.03 [0.73, 1.44]
0
F
1.02 [0.48, 2.16]
0
F
Genotyping method
PCR-RFLP
5
1564/1539
1.02 [0.90, 1.15]
48.1
F
1.11 [0.81, 1.52]
17.1
F
1.00 [0.85, 1.18]
28.9
F
1.01 [0.86, 1.18]
39.7
F
0.92 [0.56, 1.52]
2.5
F
TaqMan
6
2681/2979
1.12 [1.02, 1.23]
0
F
1.27 [0.98, 1.64]
0
F
1.10 [0.98, 1.24]
0
F
1.12 [1.01, 1.26]
0
F
1.23 [0.95, 1.58]
0
F
Other methods
4
1611/1869
1.16 [1.03, 1.32]
18.7
F
1.50 [1.06, 2.13]
0
F
1.12 [0.96, 1.31]
22.8
F
1.16 [1.00, 1.35]
25.1
F
1.431.02, 2.01]
0
F
Abbreviations: CI = confidence interval; OR = odds ratio; F = fixed-effects mode; R = random-effects model; HB = hospital based; PB = population based.
