The Effect of Autologous Adipose-Derived Stromal Vascular Fractions on Cartilage Regeneration Was Quantitatively Evaluated Based on the 3D-FS-SPGR Sequence: A Clinical Trial Study
Table 5
MOCART changes during 12-month follow-up.
Variables
Maximum score
Group test (grade 2/3), (%)
Group control (grade 2/3), (%)
6 months
12 months
6 months
12 months
1. Degree of defect repair and filling of the defect
Complete
20
0 (0)/0 (0)
2 (6.90)/1 (4.17)
0 (0)/0 (0)
0 (0)/0 (0)
Hypertrophy
15
9 (31.03)/5 (20.83)
10 (34.48)/8 (33.33)
2 (7.41)/0 (0)
2 (7.41)/0 (0)
Incomplete
>50% of the adjacent cartilage
10
12 (41.38)/9 (37.50)
13 (44.83)/10 (41.66)
4 (14.81)/2 (8.33)
3 (11.11)/1 (4.17)
<50% of the adjacent cartilage
5
7 (21.14)/7 (29.17)
4 (13.79)/4 (16.67)
11 (40.74)/7 (29.17)
11 (40.74)/6 (25.00)
Subchondral bone exposed
0
1 (3.45)/3 (12.50)
0 (0)/1 (4.17)
10 (37.04)/15 (62.50)
11 (40.74)/17 (70.83)
2. Integration to the border zone
Complete
15
7 (21.14)/4 (16.67)
14 (48.28)/7 (29.16)
0 (0)/0 (0)
0 (0)/0 (0)
Incomplete
Demarcating border visible (split-like)
10
17 (58.62)/10 (41.67)
12 (41.38)/9 (37.50)
5 (18.52)/3 (12.50)
4 (14.81)/3 (12.50)
Defect visible
<50% of length of the repair tissue
5
3 (10.34)/7 (29.17)
3 (10.34)/6 (25.00)
11 (40.74)/7 (29.17)
12 (44.45)/6 (25.00)
>50% of length of the repair tissue
0
2 (6.90)/3 (12.50)
0 (0)/2 (8.33)
11 (40.74)/14 (58.33)
11 (40.74)/15 (62.50)
3. Surface of the repair tissue
Surface intact
10
16 (55.17)/13 (54.17)
19 (65.52)/16 (66.67)
1 (3.70)/0 (0)
1 (3.70)/0 (0)
Surface damaged
<50% of repair tissue depth
5
11 (37.93)/9 (37.50)
10 (34.48)/7 (29.16)
14 (51.85)/8 (33.33)
12 (44.45)/7 (29.17)
>50% of repair tissue depth or total degeneration
0
2 (6.90)/2 (8.33)
0 (0)/1 (4.17)
12 (44.45)/16 (66.67)
14 (51.85)/17 (70.83)
4. Structure of the repair tissue
Homogeneous
5
20 (68.97)/16 (66.67)
23 (79.31)/19 (79.17)
9 (33.33)/5 (20.83)
8 (29.63)/7 (29.17)
Inhomogeneous or cleft formation
0
9 (31.03)/8 (33.33)
6 (20.69)/5 (20.83)
18 (66.67)/19 (79.17)
19 (70.37)/17 (70.83)
5. Signal intensity of repair tissue
Normal (identical to adjacent cartilage)
30
2 (6.90)/1 (4.17)
7 (24.14)/3 (12.50)
2 (7.41)/1 (4.17)
2 (7.41)/0 (0)
Nearly normal (slight areas of signal alteration)
15
20 (68.96)/16 (66.67)
18 (62.07)/17 (70.83)
7 (25.92)/5 (20.83)
6 (22.22)/5 (20.83)
Abnormal (large areas of signal alteration)
0
7 (21.14)/7 (29.16)
4 (13.79)/4 (16.67)
18 (66.67)/18 (75.00)
19 (70.37)/19 (79.17)
6. Subchondral lamina
Intact
5
21 (72.41)/17 (70.83)
21 (72.41)/20 (83.33)
12 (44.44)/7 (29.17)
7 (37.04)/4 (16.67)
Not intact
0
8 (27.59)/7 (29.17)
8 (27.59)/4 (16.67)
15 (55.56)/17 (70.83)
17 (62.96)/20 (83.33)
7. Subchondral bone
Intact
5
8 (27.59)/8 (33.33)
8 (27.59)/11 (45.83)
6 (22.22)/6 (25.00)
4 (14.81)/4 (16.67)
Not intact (edema, granulation tissue, cysts, sclerosis)
