Network Pharmacology and Molecular Docking Analysis to Explore the Mechanism of Huaiqihuang-Mediated Alleviation of Henoch–Schönlein Purpura Nephritis

Table 4

Top 10 KEGG pathway analyses for the treatment of HSPN.

Rank	Pathways	value	Enrichment	Targets
1	Cytokine-cytokine receptor interaction		0.027119	IL1B, IL6, CXCL8, IL10, IL18, CCL2, TGFB1, TNF
2	NOD-like receptor signaling pathway		0.038043	IL1B, IL6, CXCL8, IL18, CCL2, TLR4, TNF
3	IL-17 signaling pathway		0.06383	IL1B, IL6, CXCL8, MMP9, CCL2, TNF
4	Viral protein interaction with cytokine and cytokine receptor		0.06	IL6, CXCL8, IL10, IL18, CCL2, TNF
5	Toll-like receptor signaling pathway		0.057692	AKT1, IL1B, IL6, CXCL8, TLR4, TNF
6	HIF-1 signaling pathway		0.055046	AKT1, IGF1, IL6, SERPINE1, STAT3, TLR4
7	TNF signaling pathway		0.053571	AKT1, IL1B, IL6, MMP9, CCL2, TNF
8	FoxO signaling pathway		0.045802	AKT1, IGF1, IL6, IL10, STAT3, TGFB1
9	C-type lectin receptor signaling pathway		0.048077	AKT1, IL1B, IL6, IL10, TNF
10	NF-κB signaling pathway		0.038462	IL1B, CXCL8, TLR4, TNF