Genotoxicity Evaluation of Metformin in Freshwater Planarian Dugesia japonica by the Comet Assay and RAPD Analysis

Figure 1

Morphological changes of D. japonica treated with metformin at different concentrations. The control group of planarians (a) and those exposed to 10 mmol/L metformin (b) have normal morphology. Planarians exposed to 50 mmol/L metformin appeared to exhibit bridge-like position (c), screw-like hyperkinesia (d), and C-like position (e).

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