Nuclear Transporting Factor 2 as a Novel Biomarker of Head and Neck Squamous Cell Carcinoma and Associated with T/B Cell Receptor Signaling Pathway

Table 3

Top 10 most significant compounds based on cMap analysis.

cMap name	Score	Target	MOA
Benzbromarone	-99.93	ABCC1, SLC22A12	Chloride channel blocker
Mosapride	-99.89	HTR4, HTR3A	Serotonin receptor agonist
ITE	-99.89	AHR	Aryl hydrocarbon receptor agonist
Azathioprine	-99.89	HPRT1, IMPDH1, PPAT	Dehydrogenase inhibitor
Orphenadrine	-99.86	CYP2B6, GRIN1, GRIN2D, GRIN3A, GRIN3B, HRH1, SCN10A, SLC6A2	Acetylcholine receptor antagonist
H-9	-99.86	PRKACA	PKA inhibitor
Pergolide	-99.86	DRD1, DRD2, ADRA2A, ADRA2B, ADRA2C, DRD3, DRD4, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, ADRA1A, ADRA1B, ADRA1D, KCNA5	Dopamine receptor agonist
Protriptyline	-99.82	SLC6A2, SLC6A4	Tricyclic antidepressant
CITCO	-99.82	NR1I3	CAR agonist
Rhamnetin	-99.79	ALOX5, MAPK8	HDAC inhibitor

MOA: mode of action.