The Anticancer Role of Cerium Oxide Nanoparticles by Inducing Antioxidant Activity in Esophageal Cancer and Cancer Stem-Like ESCC Spheres

Figure 2

The resazurin assay result shows the effect of CNPs on cell viability of YM1 and CSC-LC cell lines. CNPs can cause ESCC cell death in both YM1 (ESCC) and CSC-LC cell lines in a dose- and time-dependent manner. Section (a): IC₅₀s in CSC-LC treated with CNPs are 968 μM and 840 μM after 24 and 48 hours, respectively. Section (b): IC₅₀s in YM1 cell line treated with CNPs are 758 μM and 630 μM after 24 and 48 hours, respectively. ( shows a significant difference between each concentration and the control group) ( value < 0.05, value < 0.01, value < 0.001, value < 0.0001) (CNP: cerium oxide nanoparticle).

(a)

(b)