Antiproliferative Activity of Two Unusual Dimeric Flavonoids, Brachydin E and Brachydin F, Isolated from Fridericia platyphylla (Cham.) L.G.Lohmann: In Vitro and Molecular Docking Evaluation

Table 1

Mean and standard deviation of IC50 values for the crude hydroethanolic extract, subfraction, and isolated compounds obtained from Fridericia platyphylla roots in human tumor cell lines after 48 h of treatment.

IC50 (μg.mL^−1/μM)	U-251	NCI-H460	PC-3	HT-29	HaCaT
Doxorubicin hydrochloride	>10/>17.2	>10/>17.2		>10/>17.2
Crude hydroethanolic extract		>100	>100	>100	>100
Subfraction		>100	42.5 ± 6.5	>100	>100
Brachydin E
Brachydin F				>100/>112.4

IC₅₀: half maximal inhibitory concentration; doxorubicin hydrochloride: positive control; human cell lines: U-251 (glioblastoma), NCI-H460 (lung, non-small-cells), PC-3 (prostate), HT-29 (colon), HaCat (keratinocytes, nontumoral).