Antiproliferative Activity of Two Unusual Dimeric Flavonoids, Brachydin E and Brachydin F, Isolated from Fridericia platyphylla (Cham.) L.G.Lohmann: In Vitro and Molecular Docking Evaluation

Table 2

Selective index values for doxorubicin hydrochloride (chemotherapy) and isolated compounds obtained from Fridericia platyphylla roots in human tumor cell lines after 48 h of treatment.

	U-251	NCI-H460	PC-3	HT-29
Doxorubicin hydrochloride	UD	UD	2.1	UD
Brachydin E	0.9	2.2	8.6	0.5
Brachydin F	1.4	0.7	1.8	UD

UD: undetermined. SI value greater than or equal to 2.0 was adopted as significant. Human cell lines: U-251 (glioblastoma), NCI-H460 (lung, non-small-cells), PC-3 (prostate), HT-29 (colon).