[Retracted] LINC00518 Promotes Cell Malignant Behaviors via Influencing EIF4A3-Mediated mRNA Stability of MITF in Melanoma

Figure 1

LINC00518 is upregulated in melanoma, and LINC00518 inhibits multiple malignant behaviors of melanoma cells. (a) The level of LINC00518 in melanoma tumor tissues and noncancerous tissues was projected on the GEPIA database. (b) The GEPIA database demonstrated the overall survival of patients in the high/low LINC00518 group. (c) The level of LINC00518 in melanoma cell lines (B16, A2058, and A375) and the human epidermal melanocytes (HEMn) was examined by RT-qPCR. (d) RT-qPCR assays measured knockdown efficiency of sh-LINC00518#1/2. (e) CCK-8 assays were done to examine proliferative ability of cells upon LINC00518 knockdown. (f) Number of formed colonies was detected by colony formation assays after LINC00518 deficiency. (g) Transwell assays evaluated the migration of melanoma cells upon LINC00518 depletion. (h) The influences of LINC00518 knockdown on the expression of key proteins related to invasion, migration, and EMT were assessed in western blot assays. ; .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)