Diagnostic and Prognostic Roles of Thrombospondin-2 in Digestive System Cancers

Table 1

Characteristics of included studies related to diagnosis.

First author	Year	Journal	Location	Disease	Sample size	Cut-offs (ng/ml)	Patients ()	Controls ()	TP ()	FP ()	FN ()	TN ()
Kim [25]	2017	Science Translational Medicine	USA	Pancreatic cancer	498	42	278	220	122	3	156	217
Berger [34]	2019	Theranostics	Europe	Pancreatic cancer	99	42	52	47	24	2	28	45
Byrling [35]	2021	Clinical and Translational Oncology	Europe	PDAC+dCAA	155	42	103	52	72	2	31	50
Le Large [36]	2020	The Oncologist	Europe	PDAC+dCAA	132	40.9	82	50	41	2	41	48
Peng [37]	2018	Annals of Surgical Oncology	China	Pancreatic cancer	493	29.8	263	230	147	0	116	230
Zhang [27]	2017	British Journal of Cancer	China	Hepatocellular carcinoma	74	36.9	44	30	35	2	9	28
Li [26]	2021	Journal of Oncology	China	Gastric cancer	87	—	46	41	36	7	10	34
Fei [10]	2017	Oncotarget	China	Colorectal cancer	620	14.85	402	218	260	28	142	190
Chen [38]	2010	Pancreas	USA	Pancreatic cancer	73	—	37	36	18	2	19	34

TP: true positive; FP: false positive; FN: false negative; TN: true negative; PDAC: pancreatic ductal adenocarcinoma; dCAA: distal cholangiocarcinoma.