Upregulation of Centromere Proteins as Potential Biomarkers for Esophageal Squamous Cell Carcinoma Diagnosis and Prognosis

Table 1

Univariate Cox regression analysis of ESCC patients’ overall survival in TCGA.

Characteristics		Total (%)	HR (95% CI)
Sex	Female vs. male	15 (15.8%) vs. 80 (84.2%)	0.175 (0.041-0.756)	0.020
Race	White+other vs. Asian; Missing	47 (49.5%) vs. 45 (47.4%); 3 (3.2%)	1.570 (0.688-3.581)	0.284
Age	≥60 vs. <60	39 (41.1%) vs. 56 (58.9%)	1.296 (0.631-2.662)	0.461
T stage	T3+T4 vs. T1+T2; Missing	54 (56.8%) vs. 40 (42.1%); 1 (1.1%)	1.351 (0.649-2.811)	0.422
N stage	N2+N3 vs. N0+N1; Missing	9 (9.5%) vs. 84 (88.4%); 2 (2.1%)	3.265 (1.302-8.189)	0.012
TNM stage	III+IV vs. I+II; Missing	31 (32.6%) vs. 63 (66.3%); 2 (2.1%)	2.443 (1.191-5.011)	0.015
Tumor grade	G3 vs. G1+G2; Missing	21 (22.1%) vs. 65 (68.4%); 9 (9.5%)	0.736 (0.277-1.950)	0.537
Tumor location	Lower vs. upper+middle; Missing	44 (46.3%) vs. 50 (52.6%); 1 (1.1%)	0.958 (0.448-2.051)	0.913
Tobacco use	Yes vs. no	51 (53.7%) vs. 44 (46.3%)	1.965 (0.901-4.285)	0.089
Alcohol use	Yes vs. no; Missing	68 (71.6%) vs. 25 (26.3%); 2 (2.1%)	2.172 (0.751-6.276)	0.152

HR: hazard ratio; CI: confidence interval; TNM: tumor-node-metastasis; .