The Twofold Role of Osteogenic Small Molecules in Parkinson’s Disease Therapeutics: Crosstalk of Osteogenesis and Neurogenesis

Figure 3

(a) Smad MH2 domain bound to DNA (PDB: 1MHD). (b) PY motif in the linker region of Smad1 bound to the WW domain of Smurf1. The small molecule that occupies this pocket of the binding site inhibits Smad1 ubiquitination (PDB: 2LAZ).

(a)

(b)