The Twofold Role of Osteogenic Small Molecules in Parkinson’s Disease Therapeutics: Crosstalk of Osteogenesis and Neurogenesis

Table 1

Crosstalk of osteogenic small molecules involve in Smad1/3/5, BMP2, and Smurf1 signaling pathway.

	Small molecule	Parkinson’s disease
Smad3 and p-Smad3	Pitavastatin	May apply
	Mevastatin	May apply
	Simvastatin	May apply
	Sirolimus	May apply
Smad1/5 and p-Smad1/5	Isoliquiritigenin	May apply
	4-hydroxychalcone	May apply
	FK506	May apply
	PGE-5516909	May apply
Smurf1 inhibitors	C22H20ClF3N4O3S	Not apply
	C25H26FN3O4	Not apply
	Phenamil	Not apply
BMP2	2-((1-(benzyl(2-hydroxy-2-phenylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl) benzoic acid	May apply