Association between XRCC3 rs861539 Polymorphism and the Risk of Ovarian Cancer: Meta-Analysis and Trial Sequential Analysis

Table 3

Meta-analysis results of XRCC3 rs861539 polymorphism in different subgroups.

Genetic models	Subgroup	(%)	Model for analysis		OR (95% CI)
G versus A	Ethnicity
	Caucasian	25.7	FEM	0.207	1.07 (1.01, 1.13)	0.017
	Asian	NA	FEM	NA	1.00 (0.40, 2.48)	1.0
	Mixed	NA	FEM	NA	1.00 (0.60, 1.66)	1.0
	Control source
	Population	0.0	FEM	0.865	1.04 (0.98, 1.12)	0.194
	Hospital	57.3	REM	0.071	1.08 (0.86, 1.35)	0.496
	Detection method
	TaqMan	0.0	FEM	0.675	1.04 (0.97, 1.12)	0.264
	Sequencing	0.0	FEM	0.909	1.05 (0.91, 1.22)	0.491
	PCR-RFLP	58.4	REM	0.065	1.08 (0.87, 1.33)	0.50
GG versus AA	Ethnicity
	Caucasian	13.4	FEM	0.319	1.12 (0.99, 1.26)	0.069
	Asian	NA	FEM	NA	0.21 (0.01, 4.39)	0.31
	Mixed	NA	FEM	NA	1.00 (0.26, 3.79)	1.0
	Control source
	Population	0.0	FEM	0.910	1.04 (0.90, 1.20)	0.603
	Hospital	46.4	FEM	0.133	1.30 (1.05, 1.62)	0.016
	Detection method
	TaqMan	0.0	FEM	0.745	1.04 (0.89, 1.22)	0.611
	Sequencing	4.4	FEM	0.306	1.00 (0.73, 1.37)	0.996
	PCR-RFLP	30.9	FEM	0.227	1.31 (1.06, 1.62)	0.013
GA versus GG	Ethnicity
	Caucasian	8.2	FEM	0.367	0.88 (0.81, 0.96)	0.004
	Asian	NA	FEM	NA	0.58 (0.20, 1.70)	0.321
	Mixed	NA	FEM	NA	1.00 (0.50, 1.99)	1.0
	Control source
	Population	0.0	FEM	0.613	0.90 (0.82, 0.99)	0.029
	Hospital	27.7	FEM	0.246	0.81 (0.67, 0.98)	0.028
	Detection method
	TaqMan	0.0	FEM	0.420	0.91 (0.81, 1.01)	0.084
	Sequencing	0.0	FEM	0.50	0.83 (0.67, 1.03)	0.097
	PCR-RFLP	26.7	FEM	0.252	0.83 (0.69, 1.00)	0.048
GG+GA versus AA	Ethnicity
	Caucasian	0.0	FEM	0.607	1.04 (0.94, 1.16)	0.434
	Asian	NA	FEM	NA	5.15 (0.24, 109.15)	0.29
	Mixed	NA	FEM	NA	1.00 (0.28, 3.62)	1.0
	Control source
	Population	0.0	FEM	0.879	0.98 (0.86, 1.12)	0.815
	Hospital	13.8	FEM	0.323	1.14 (0.96, 1.35)	0.135
	Detection method
	TaqMan	0.0	FEM	0.709	1.00 (0.86, 1.16)	0.958
	Sequencing	1.3	FEM	0.314	0.92 (0.68, 1.23)	0.568
	PCR-RFLP	0.0	FEM	0.528	1.15 (0.97, 1.36)	0.116
GG versus GA+AA	Ethnicity
	Caucasian	28.0	FEM	0.187	0.89 (0.82, 0.96)	0.004
	Asian	NA	FEM	NA	0.77 (0.29, 2.09)	0.614
	Mixed	NA	FEM	NA	1.00 (0.51, 1.94)	1.0
	Control source
	Population	0.0	FEM	0.702	0.91 (0.83, 1.00)	0.05
	Hospital	52.6	REM	0.097	0.86 (0.62, 1.19)	0.358
	Detection method
	TaqMan	0.0	FEM	0.494	0.92 (0.83, 1.02)	0.114
	Sequencing	0.0	FEM	0.815	0.87 (0.71, 1.07)	0.179
	PCR-RFLP	55.4	REM	0.081	0.89 (0.64, 1.22)	0.462

Bonferroni correction for multiple testing was applied (ethnicity and detection method group: value threshold 0.016; control source group: value threshold 0.025).