The Impact of a History of Different Other Cancers on the Long-Term Outcomes of Patients with Intrahepatic Cholangiocarcinoma: A Population-Based Analysis
Table 1
Baseline characteristics of included ICC patients.
Variable
Overall, (%)
Without prior malignancies, (%)
With prior malignancies, (%)
value
Total
9667
8885 (91.91)
782 (8.09)
Age, years
<0.001
≤65
4546 (47.03)
4317 (48.59)
229 (29.28)
>65
5121 (52.97)
4568 (51.41)
553 (70.72)
Sex
<0.001
Male
4793 (49.58)
4332 (48.76)
461 (58.95)
Female
4874 (50.42)
4553 (51.24)
321 (41.05)
Race
0.001
White
7663 (79.27)
7014 (78.94)
649 (82.99)
Black
738 (7.63)
674 (7.59)
64 (8.18)
Others
1266 (13.10)
1197 (13.47)
69 (8.82)
Marital status
0.269
Single
3533 (36.55)
3265 (36.75)
268 (34.27)
Married
5747 (59.45)
5261 (59.21)
486 (62.15)
Unknown
387 (4.00)
359 (4.04)
28 (3.58)
AFP
0.001
Negative
2956 (30.58)
2747 (30.92)
209 (26.73)
Positive
1190 (12.31)
1114 (12.54)
76 (9.72)
Unknown
5521 (57.11)
5024 (56.54)
497 (63.55)
AJCC stage
<0.001
I
1697 (17.55)
1481 (16.67)
216 (27.62)
II
1227 (12.69)
1107 (12.46)
120 (15.35)
III
2021 (20.91)
1843 (20.74)
178 (22.76)
IV
2908 (30.08)
2714 (30.55)
194 (24.81)
Unknown
1814 (18.76)
1740 (19.58)
74 (9.46)
Tumor size, cm
<0.001
<5 cm
2478 (25.63)
2185 (24.59)
293 (37.47)
5-8 cm
1920 (19.86)
1792 (30.17)
128 (16.37)
≥8 cm
2207 (22.83)
2073 (23.33)
134 (17.14)
Unknown
3062 (31.67)
2835 (31.91)
227 (29.03)
Vascular invasion
0.006
No
4521 (46.77)
4113 (46.29)
408 (52.17)
Yes
2252 (23.30)
2084 (23.46)
168 (21.48)
Unknown
2894 (29.94)
2688 (30.25)
206 (26.34)
Grade
0.019
I/II
2507 (25.93)
2283 (25.69)
224 (28.64)
III/IV
1738 (17.98)
1624 (18.28)
114 (14.58)
Unknown
5422 (56.09)
4978 (56.03)
444 (56.78)
Treatment
<0.001
None
7075 (73.19)
6574 (73.99)
501 (64.07)
Local tumor destruction
224 (2.32)
194 (2.18)
30 (3.84)
Surgery
2285 (23.64)
2041 (22.97)
244 (31.20)
Unknown
83 (0.86)
76 (0.86)
7 (0.90)
Radiation
0.293
None
8078 (83.56)
7412 (83.42)
666 (85.17)
Yes
1537 (15.90)
1423 (16.02)
114 (14.58)
Unknown
52 (0.54)
50 (0.56)
2 (0.26)
Chemotherapy
0.019
None/unknown
4054 (41.94)
3695 (41.59)
359 (45.91)
Yes
5613 (58.06)
5190 (58.41)
423 (54.09)
Note: ICC: intrahepatic cholangiocarcinoma; AFP: alpha-fetoprotein; AJCC: American Joint Committee on Cancer.
