The Impact of a History of Different Other Cancers on the Long-Term Outcomes of Patients with Intrahepatic Cholangiocarcinoma: A Population-Based Analysis
Table 2
Univariate and multivariate Cox regression analyses of OS and CSS for ICC patients.
Variable
OS
CSS
Univariate analysis
Multivariate analysis
Univariate analysis
Multivariate analysis
HR (95% CI)
value
HR (95% CI)
value
HR (95% CI)
value
HR (95% CI)
value
Prior cancers
<0.001
0.002
<0.001
<0.001
No
Reference
Reference
Reference
Reference
Yes
0.822 (0.752-0.896)
0.870 (0.797-0.950)
0.754 (0.683-0.832)
0.820 (0.741-0.906)
Age, years
<0.001
<0.001
<0.001
<0.001
≤65
Reference
Reference
Reference
Reference
>65
1.267 (1.211-1.325)
1.233 (1.177-1.292)
1.267 (1.208-1.329)
1.214 (1.156-1.275)
Sex
<0.001
<0.001
<0.001
<0.001
Male
Reference
Reference
Reference
Reference
Female
0.900 (0.860-0.941)
0.891 (0.851-0.933)
0.908 (0.865-0.952)
0.894 (0.852-0.939)
Race
0.906
0.947
White
Reference
Reference
Black
0.986 (0.905-1.075)
0.985 (0.900-1.079)
Others
0.988 (0.924-1.057)
0.996 (0.928-1.069)
Marital status
<0.001
0.004
0.001
0.004
Single
Reference
Reference
Reference
Reference
Married
0.914 (0.872-0.958)
0.950 (0.905-0.997)
0.914 (0.870-0.961)
0.943 (0.896-0.992)
Unknown
0.875 (0.777-0.986)
0.832 (0.738-0.938)
0.861 (0.757-0.979)
0.826 (0.726-0.940)
AFP
<0.001
<0.001
<0.001
<0.001
Negative
Reference
Reference
Reference
Reference
Positive
1.304 (1.212-1.403)
1.166 (1.083-1.255)
1.330 (1.232-1.435)
1.201 (1.112-1.297)
Unknown
1.159 (1.101-1.219)
1.017 (0.965-1.072)
1.165 (1.104-1.229)
1.030 (1.213-1.402)
AJCC stage
<0.001
<0.001
<0.001
<0.001
I
Reference
Reference
Reference
Reference
II
1.433 (1.312-1.566)
1.432 (1.303-1.574)
1.500 (1.364-1.650)
1.486 (1.342-1.645)
III
1.763 (1.632-1.904)
1.642 (1.510-1.785)
1.849 (1.701-2.010)
1.718 (1.570-1.879)
IV
2.835 (2.635-3.050)
1.966 (1.812-2.132)
2.968 (2.743-3.211)
2.023 (1.855-2.207)
Unknown
1.902 (1.758-2.059)
1.348 (1.237-1.469)
1.977 (1.815-2.155)
1.391 (1.267-1.526)
Tumor size, cm
<0.001
<0.001
<0.001
<0.001
<5 cm
Reference
Reference
Reference
Reference
5-8 cm
1.235 (1.152-1.325)
1.148 (1.069-1.233)
1.273 (1.181-1.372)
1.169 (1.083-1.261)
≥8 cm
1.539 (1.439-1.645)
1.223 (1.140-1.311)
1.591 (1.482-1.708)
1.246 (1.157-1.341)
Unknown
2.066 (1.942-2.197)
1.264 (1.181-1.352)
2.165 (2.027-2.313)
1.304 (1.213-1.402)
Vascular invasion
<0.001
0.072
<0.001
0.075
No
Reference
Reference
Reference
Reference
Yes
1.075 (1.015-1.138)
1.000 (0.940-1.064)
1.089 (1.025-1.157)
1.016 (0.953-1.085)
Unknown
1.318 (1.250-1.390)
0.938 (0.886-0.994)
1.331 (1.259-1.407)
0.942 (0.887-1.001)
Grade
<0.001
<0.001
<0.001
<0.001
I/II
Reference
Reference
Reference
Reference
III/IV
1.512 (1.408-1.624)
1.281 (1.193-1.377)
1.523 (1.412-1.642)
1.286 (1.192-1.388)
Unknown
1.988 (1.879-2.102)
1.178 (1.109-1.253)
2.029 (1.911-2.154)
1.197 (1.123-1.277)
Treatment
<0.001
<0.001
<0.001
<0.001
None
Reference
Reference
Reference
Reference
Local tumor destruction
0.426 (0.364-0.499)
0.473 (0.403-0.556)
0.422 (0.355-0.501)
0.469 (0.394-0.559)
Surgery
0.276 (0.259-0.294)
0.324 (0.301-0.348)
0.263 (0.246-0.282)
0.312 (0.289-0.337)
Unknown
1.132 (0.905-1.415)
0.995 (0.792-1.250)
1.278 (1.010-1.618)
1.044 (0.821-1.328)
Radiation
<0.001
<0.001
<0.001
<0.001
None
Reference
Reference
Reference
Reference
Yes
0.810 (0.761-0.863)
0.816 (0.765-0.869)
0.807 (0.755-0.862)
0.823 (0.770-0.881)
Unknown
0.854 (0.620-1.174)
1.078 (0.783-1.484)
0.847 (0.608-1.181)
1.111 (0.796-1.550)
Chemotherapy
0.037
<0.001
0.023
<0.001
None/unknown
Reference
Reference
Reference
Reference
Yes
0.952 (0.910-0.997)
0.694 (0.660-0.730)
0.945 (0.900-0.992)
0.671 (0.636-0.708)
Note: ICC: intrahepatic cholangiocarcinoma; AFP: alpha-fetoprotein; AJCC: American Joint Committee on Cancer; HR: hazard ratio; CI: confidence interval; OS: overall survival; CSS: cancer specific survival.
