[Retracted] HDAC3 Inhibition Alleviates High-Glucose-Induced Retinal Ganglion Cell Death through Inhibiting Inflammasome Activation

Figure 3

HDAC3 inhibition protected HG-treated RGCs from cell death, MMP impairment, cytotoxicity, and oxidative stress. (a) The cell death of HG groups was significantly higher than that of normal, while HDAC3 inhibition significantly alleviated the cell death rate. The green points represented the live cells, and the red points represented the dead cells. (b) The MMP status detected using JC-1 of normal, HG, and HG+RGFP966 cotreatment RGC groups. (c) The relative LDH release of normal, HG, and HG+RGFP966 cotreatment RGC groups. (d) The relative content of SOD in normal, HG, and HG+RGFP966 cotreatment RGC groups. (e) The relative content of GSH in normal, HG, and HG+RGFP966 cotreatment RGC groups. , based on Student’s -test.

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