Maackiain Prevents Amyloid-Beta–Induced Cellular Injury via Priming PKC-Nrf2 Pathway

<div>Effects of Nrf2 siRNA and calphostin C on PC12 cell injury. (a) Nrf2 and control siRNAs were transfected into PC12 cells. At 24 hours after transfection, the Nrf2 levels in PC12 cells were determined by immunoblotting. Prior to Maackiain (100 <i>μ</i>M) treatment, PC12 cells were transfected with Nrf2 siRNA or incubated with calphostin C for 1 hour and then exposed to A<i>β</i><sub>42.</sub> CCK-8 (b) and LDH activity (c) assay were performed to detect cell viability and injury severity. 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BioMed Research International

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Figure 5

Figure 5: Maackiain Prevents Amyloid-Beta–Induced Cellular Injury via Priming PKC-Nrf2 Pathway 