[Retracted] Activating IL-6/STAT3 Enhances Protein Stability of Proteasome 20S α+β in Colorectal Cancer by miR-1254

Figure 8

miR-1254 targeting PSMD10 mediated proteasome 20S α+β degradation in vivo. The nude mice had injected with the HCT116 cells subcutaneously. When the tumor size reached around 5 mm, the mice were separated into three groups randomly. PBS, IL-6, and IL-6+miR-1254s were injected intratumorally into mice. The animals were slaughtered four weeks following the treatment, and their tumor growth was monitored. (a) Comparison of excised tumor size in each group. (b) The weight of tumor for the 4 xenograft tumor groups. (c) The curves of tumor growth volume of the three xenograft tumor groups. (d) RT-PCR was used to investigate the expression levels of miR-1254 in the implanted tumors. (e) Immunohistochemistry was used to detect the expression of p-STAT3, PAMD10, and proteasome 20S α+β in xenograft tumors groups. The scale bar measures 50 μm. All data were presented as , with compared to the PBS group and compared to the PBS group.

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