Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population
Table 2
Genotypic distribution of 12 SIRT gene between CAD patients () and controls ().
SNP
Genotype
Case (%)
Control (%)
valuea (2)
valueb
OR (95% CI)
SIRI1
rs12778366
TT
382 (75.0)
426 (77.2)
0.222
Referent
1.00
TC
116 (22.8)
121 (21.9)
0.651
1.069 (0.800-1.428)
CC
11 (2.2)
5 (0.9)
0.099
2.453 (0.845-7.125)
127 (25.0)
126 (22.8)
0.417
1.124 (0.847-1.491)
rs3758391
TT
377 (74.1)
403(73.0)
0.030
Referent
1.00
TC
110 (21.6)
139(25.2)
0.253
0.846 (0.635-1.127)
CC
22 (4.3)
10(1.8)
0.028
2.352 (1.099-5.032)
132 (25.9)
149 (27.0)
0.696
0.947 (0.721-1.244)
rs3740051
AA
275 (54.0)
302(54.7)
0.139
Referent
1.00
AG
192 (37.7)
221(40.0)
0.716
0.954 (0.741-1.229)
GG
42 (8.3)
29 (5.3)
0.069
1.590 (0.964-2.624)
234(46.0)
250 (45.3)
0.824
1.028 (0.807-1.309)
rs4746720
CC
92 (18.1)
129 (23.4)
0.102
Referent
1.00
CT
246 (48.3)
246 (44.6)
0.039
1.402 (1.018-1.932)
TT
171 (33.6)
177 (32.1)
0.080
1.355 (0.964-1.903)
CT + TT
417 (81.9)
423 (76.6)
0.034
1.382 (1.024-1.865)
rs7895833
GG
270 (53.0)
292 (52.9)
0.051
Referent
1.00
GA
187 (36.7)
225 (40.8)
0.412
0.899 (0.697-1.160)
AA
52 (10.2)
35 (6.3)
0.043
1.607 (1.015-2.544)
239 (47.0)
260 (47.1)
0.962
0.994 (0.781-1.265)
rs932658
AA
364 (71.5)
383(69.4)
0.365
Referent
1.00
AC
126 (24.8)
154(27.9)
0.287
0.861 (0.653-1.134)
CC
19 (3.7)
15 (2.7)
0.416
1.333 (0.667-2.663)
145 (28.5)
169 (30.6)
0.448
0.903 (0.693-1.176)
SIRT2
rs2015
GG
134 (26.3)
165 (29.9)
0.096
Referent
1.00
GT
256 (50.3)
241 (43.7)
0.068
1.308 (0.981-1.744)
TT
119 (23.4)
146 (26.4)
0.983
1.004 (0.720-1.399)
375 (73.7)
387 (70.1)
0.197
1.193 (0.912-1.561)
SIRT3
rs28365927
GG
397 (78.0)
413 (74.8)
≤0.01
Referent
1.00
GA
108 (21.2)
112 (20.3)
0.984
1.003 (0.745-1.351)
AA
4 (0.8)
27 (4.9)
0.001
0.154 (0.053-0.444)
112 (22.0)
139 (25.2)
0.224
0.838 (0.631-1.114)
rs11246020
CC
397 (78.0)
417 (75.5)
0.009
Referent
1.00
CT
105 (20.6)
135(24.5)
0.171
0.817 (0.611-1.091)
TT
7 (1.4)
0 (0.0)
0.999
—
112 (22.0)
135 (24.5)
0.345
0.871 (0.655-1.160)
SIRT6
rs350844
GG
224 (44.0)
287 (52.0)
0.004
Referent
1.00
GA
235 (46.2)
235 (42.6)
0.053
1.281 (0.996-1.648)
AA
50 (9.8)
30 (5.4)
0.002
2.135 (1.315-3.469)
285 (56.0)
265 (48.0)
0.009
1.378 (1.082-1.755)
rs350846
GG
224 (44.0)
296 (53.6)
0.002
Referent
1.00
GC
237 (46.6)
226 (40.9)
0.011
1.386 (1.077-1.782)
CC
48 (9.4)
30 (5.4)
0.003
2.114 (1.298-3.445)
GC + CC
285 (56.0)
256(46.4)
0.002
1.471 (1.155-1.874)
rs107251
CC
224 (44.0)
307 (55.6)
≤0.01
Referent
1.00
CT
241 (47.3)
215 (38.9)
0.001
1.536 (1.194-1.976)
TT
44 (8.6)
30 (5.4)
0.006
2.010 (1.225-3.298)
CT + TT
285 (56.0)
245(44.4)
0.000
1.594 (1.251-2.032)
Abbreviations: CI: confidence interval; OR: odds ratio. a value for allele frequencies in cases and controls using 2-sided 2 test. b values adjusted by age and gender using logistic regression. .
