Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population
Table 3
Allelic distribution of 12 SIRT gene between all CAD patients () and controls ().
SNP
Allele
Case (%)
Control (%)
valuea (2)
valueb (2)
OR (95% CI)
SIRI1
rs12778366
T
880 (86.4)
973 (88.1)
0.242
Referent
1.00
C
138 (13.6)
131 (11.9)
0.243
1.165 (0.902-1.504)
rs3758391
T
864 (84.9)
945 (85.6)
0.638
Referent
1.00
C
154 (15.1)
159 (14.4)
0.638
1.059 (0.833-1.347)
rs3740051
A
742 (72.9)
825 (74.7)
0.335
Referent
1.00
G
276 (27.1)
279 (25.3)
0.335
1.100 (0.906-1.335)
rs4746720
C
430 (42.2)
504 (45.7)
0.114
Referent
1.00
T
588 (57.8)
600 (54.3)
0.114
1.149 (0.967-1.364)
rs7895833
G
727 (71.4)
809 (73.3)
0.337
Referent
1.00
A
291 (28.6)
295 (26.7)
0.337
1.098 (0.907-1.328)
rs932658
A
854 (83.9)
920 (83.3)
0.729
Referent
1.00
C
164 (16.1)
184 (16.7)
0.729
0.960 (0.763-1.209)
SIRT2
rs2015
G
524 (51.5)
570 (51.6)
0.996
Referent
1.00
T
494 (48.5)
534 (48.4)
0.944
1.006 (0.848-1.193)
SIRT3
rs28365927
G
902 (88.6)
938 (85.0)
0.014
Referent
1.00
A
116 (11.4)
166 (15.0)
0.014
0.727 (0.564-0.937)
rs11246020
C
899 (88.3)
969 (87.8)
0.703
Referent
1.00
T
119 (11.7)
135 (12.2)
0.703
0.950 (0.731-1.235)
SIRT6
rs350844
G
335 (32.9)
295 (26.7)
0.002
Referent
1.00
A
683 (67.1)
809 (73.3)
0.002
1.345 (1.116-1.621)
rs350846
G
333 (32.7)
286 (25.9)
0.001
Referent
1.00
C
685 (67.3)
818 (74.1)
0.001
1.390 (1.152-1.678)
rs107251
C
689 (67.7)
829 (75.1)
≤0.01
Referent
1.00
T
329 (32.3)
275 (24.9)
0.000
1.439 (1.191-1.740)
Abbreviations: CI: confidence interval; OR: odds ratio. a value for allele frequencies in cases and controls using 2-sided 2 test. b values adjusted by age and gender using logistic regression. .
