Qizhi Kebitong Formula Ameliorates Streptozocin-Induced Diabetic Osteoporosis through Regulating the PI3K/Akt/NF-κB Pathway

Table 3

The 90 active components of QKF were screened from the TCMSP database.

Drug	MOL_ID	Molecule name	OB (%)	DL
Astragalus mongholicus Bunge (Huang-qi)	MOL000211	Mairin	55.38	0.78
	MOL000239	Jaranol	50.83	0.29
	MOL000295	Alexandrin	20.63	0.63
	MOL000296	Hederagenin	36.91	0.75
	MOL000033	(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R,5S)-5-propan-2-yloctan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol	36.23	0.78
	MOL000354	Isorhamnetin	49.6	0.31
	MOL000371	3,9-Di-O-methylnissolin	53.74	0.48
	MOL000374	5-Hydroxyiso-muronulatol-2,5-di-O-glucoside	41.72	0.69
	MOL000378	7-O-Methylisomucronulatol	74.69	0.3
	MOL000379	9,10-Dimethoxypterocarpan-3-O-β-D-glucoside	36.74	0.92
	MOL000380	(6aR,11aR)-9,10-Dimethoxy-6a,11a-dihydro-6H-benzofurano[3,2-]chromen-3-ol	64.26	0.42
	MOL000387	Bifendate	31.1	0.67
	MOL000392	Formononetin	69.67	0.21
	MOL000398	Isoflavanone	109.99	0.3
	MOL000417	Calycosin	47.75	0.24
	MOL000422	Kaempferol	41.88	0.24
	MOL000433	FA	68.96	0.71
	MOL000438	(3R)-3-(2-Hydroxy-3,4-dimethoxyphenyl)chroman-7-ol	67.67	0.26
	MOL000439	Isomucronulatol-7,2-di-O-glucosiole	49.28	0.62
	MOL000440	Isomucronulatol-7,2-di-O-glucosiole_qt	23.42	0.79
	MOL000442	1,7-Dihydroxy-3,9-dimethoxy pterocarpene	39.05	0.48
	MOL000098	Quercetin	46.43	0.28
Morus alba L. (Sang-zhi)	MOL000422	Kaempferol	41.88	0.24
	MOL000729	Oxysanguinarine	46.97	0.87
	MOL000737	Morin	46.23	0.27
Spatholobus suberectus Dunn (Ji-xue-teng)	MOL000392	Formononetin	69.67	0.21
	MOL000471	Aloe-emodin	83.38	0.24
	MOL000492	(+)-Catechin	54.83	0.24
	MOL000417	Calycosin	47.75	0.24
	MOL000006	Luteolin	36.16	0.25
	MOL000461	3,7-Dihydroxy-6-methoxy-dihydroflavonol	43.8	0.26
	MOL000483	(Z)-3-(4-Hydroxy-3-methoxy-phenyl)-N-[2-(4-hydroxyphenyl)ethyl]acrylamide	118.35	0.26
	MOL000468	8-o-Methylreyusi	70.32	0.27
	MOL000501	Consume close grain	68.12	0.27
	MOL000502	Cajinin	68.8	0.27
	MOL000497	Licochalcone A	40.79	0.29
	MOL000490	Petunidin	30.05	0.31
	MOL000507	Psi-baptigenin	70.12	0.31
	MOL000503	Medicagol	57.49	0.6
	MOL000491	Augelicin	37.5	0.66
	MOL000470	8-C-α-L-Arabinosylluteolin	35.54	0.66
	MOL000493	Campesterol	37.58	0.71
	MOL000296	Hederagenin	36.91	0.75
	MOL000358	Beta-sitosterol	36.91	0.75
	MOL000449	Stigmasterol	43.83	0.76
	MOL000033	(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R,5S)-5-propan-2-yloctan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol	36.23	0.78
	MOL000469	3-Hydroxystigmast-5-en-7-one	40.93	0.78
Sigesbeckia orientalis L. (Xi-xian-cao)	MOL004180	Coronaridine	34.97	0.68
	MOL000296	Hederagenin	36.91	0.75
	MOL000358	Beta-sitosterol	36.91	0.75
	MOL004179	Vernolic acid	37.63	0.19
	MOL000449	Stigmasterol	43.83	0.76
	MOL004172	(1R)-1-[(2S,4aR,4bS,7R,8aS)-7-Hydroxy-2,4b,8,8-tetramethyl-4,4a,5,6,7,8a,9,10-octahydro-3H-phenanthren-2-yl]ethane-1,2-diol	46.7	0.31
	MOL004184	Siegesesteric acid II	51.98	0.48
	MOL004177	15alpha-Hydroxy-ent-kaur-16-en-19-oic acid	58.73	0.38
	MOL004185	Siegesmethyletheric acid	60.72	0.43
Clematis chinensis Osbeck (Wei-ling-xian)	MOL001663	(4aS,6aR,6aS,6bR,8aR,10R,12aR,14bS)-10-Hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid	32.03	0.76
	MOL002372	(6Z,10E,14E,18E)-2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene	33.55	0.42
	MOL005598	Embinin	33.91	0.73
	MOL000358	Beta-sitosterol	36.91	0.75
	MOL005594	ClematosideA_qt	37.51	0.76
	MOL005603	Heptyl phthalate	42.26	0.31
	MOL000449	Stigmasterol	43.83	0.76
Achyranthes bidentata Blume (Huai-niu-xi)	MOL001006	Poriferasta-7,22E-dien-3beta-ol	42.98	0.76
	MOL012461	28-Norolean-17-en-3-ol	35.93	0.78
	MOL012505	Bidentatoside,ii_qt	31.76	0.59
	MOL012537	Spinoside A	41.75	0.4
	MOL012542	β-Ecdysterone	44.23	0.82
	MOL001454	Berberine	36.86	0.78
	MOL001458	Coptisine	30.67	0.86
	MOL000173	Wogonin	30.68	0.23
	MOL002643	Delta 7-stigmastenol	37.42	0.75
	MOL002714	Baicalein	33.52	0.21
	MOL002776	Baicalin	40.12	0.75
	MOL002897	Epiberberine	43.09	0.78
	MOL000358	Beta-sitosterol	36.91	0.75
	MOL003847	Inophyllum E	38.81	0.85
	MOL000422	Kaempferol	41.88	0.24
	MOL004355	Spinasterol	42.98	0.76
	MOL000449	Stigmasterol	43.83	0.76
	MOL000785	Palmatine	64.6	0.65
	MOL000085	Beta-daucosterol_qt	36.91	0.75
	MOL000098	Quercetin	46.43	0.28
Scorpion (Quan-xie)	MOL011455	20-Hexadecanoylingenol	32.7	0.65
	MOL000953	Cholesterol	37.87	0.68
	MOL002223	Taurine	24.37	0.21
	MOL002156	Trimethylamine	59.98	0.18
	MOL000860	Stearic acid	17.83	0.14
	MOL002223	Taurine	24.37	0.01
	MOL000069	Palmitic acid	19.3	0.1