[Retracted] Chinese Herb Jiedu Huayu Granules Inhibiting Immune and Inflammatory Response of Rats with Acute Liver Failure by Regulating the NF-κB Signaling Pathway

Figure 2

JDHY can decline liver apoptosis in ALF rats. (a) Western blot was used to check apoptosis-related protein expression (Bax, cleaved caspase-3, and Bcl-2) in rat liver tissues. Compared with the control group (), Bax expression and cleaved caspase-3 expression were notably increased in the liver tissues of the ALF group () and Bcl-2 expression was significantly declined. While both Bax and cleaved caspase-3 expression were significantly declined in the liver tissues of ALF rats, Bcl-2 protein expression was significantly upregulated in the ALF+JDHY group () and ALF+BAY group (). (b) Immunohistochemistry was utilized to determine PCNA expression in liver tissues of rats. It indicated that the positive expression of PCNA in the liver tissues of the ALF group was notably lower compared with that of the control group. Through the addition of JDHY and BAY, the level of PCNA was increased. vs. control group (), ^## vs. ALF group ().

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