Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes

<div>Lipotoxicity induces glucose metabolic phenotypes damage and ISCs activation in vivo. (a) Body weight and circulating insulin content were detected from HFD and control rats. (b) Islet function of HFD and control rats was analyzed via IPGTT/IPITT experiment and HOME-IR value calculation. (c) Representative images of insulin/glucagon and masson’s trichrome stained in pancreatic islets from HFD and control rats. (e–f) Representative images of insulin and <i>α</i>-SMA double-stained and electron microscopy in pancreatic islet sections from HFD and control rats. Quantification of <i>α</i>-SMA fluorescent signals was measured using Image Pro Plus software. 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BioMed Research International

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Figure 1

Figure 1: Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes 