Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes

<div>The phenotype changes of ISCs from HFD rats at different in vitro culturing time. (a) Relative light microscopy micrographs of ISCs outgrowth rates from HFD and control rats at different culture time point (0 h, 48 h, 96 h, and 120 h). (b) Relative Oil red O staining of lipid droplets images of ISCs from HFD and control rats at different in vitro culturing time (48 h and 96 h). (c) Immunofluorescent staining of <i>α</i>-SMA protein expression in ISCs from HFD and control rats. 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BioMed Research International

fig2

Figure 2

Figure 2: Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes 