Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes

<div><i>Plin2</i> overexpression reverses ISCs phenotype via proliferation and fibrogenesis signaling pathways. (a) Representative photomicrographs of phenotype change in activated ISCs transduced with <i>Plin2</i> gene overexpressed or NC. (b) The protein expression of <i>α</i>-SMA, Col I, and FN in ISCs overexpressed <i>Plin2</i> was detected by western blotting. (c) The lipid accumulation observation was measured in ISCs overexpressed <i>Plin2</i>. (d) The protein expression of Smad3-TGF-<i>β</i> in ISCs overexpressed <i>Plin2</i> was detected by western blotting. 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BioMed Research International

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Figure 5

Figure 5: Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes 