Identification of Concomitant Inhibitors against Glutamine Synthetase and Isocitrate Lyase in Mycobacterium tuberculosis from Natural Sources

Table 1

Docking results of Azadiradione with two enzymes GS and ICL.

Sl. No	Compound Name	Binding affinity of the ligands with glutamine synthetase				Binding affinity of the ligands with Isocitrate Lyase
		Binding affinity (kcal/mol)	RMSD/UB	RMSD/LB	Number of H bonds formed (manually observed)	Binding affinity (kcal/mol)	RMSD/UB	RMSD/LB	Number of H-bonds observed
1	Azadiradione	-10.2	0	0	2	-8.5	0	0	2
2	7-Desacetyl-7-benzoylazadiradione	-10.1	0	0	2	-9	0	0	3
3	7-Desacetyl-7-benzoylgedunin	-9.1	0	0	2	-9.8	0	0	3
4	alpha-Amyrin	-8.8	10.503	6.395	2	-8	7.656	2.823	1
5	Gedunin	-8.7	0	0	2	-8.2	0	0	3