Olmesartan Improves Hepatic Sinusoidal Remodeling in Mice with Carbon Tetrachloride-Induced Liver Fibrosis

Figure 3

(a) A transmission electron micrograph depicting hepatic sinusoids in mice liver tissues. Representative images showed changes in the endothelial fenestrae and capillarization of the sinusoid in fibrotic mice. The fenestration structure of the mice in the CCl₄ group disappeared, and a continuous basement membrane was formed (as indicated by blue arrows), while multiple fenestrae were seen in the hepatic sinusoids of the normal mice and the olmesartan-treated mice (as shown by red arrows). S is the sinusoid, SD is the Disse space, and H is the hepatocyte. (b) A scanning electron micrograph of fenestrae in the sinusoidal endothelium of the liver of mice (as indicated by red arrows). There is defenestration of the endothelium in the CCl₄ group. E is the endothelial cell, and H is the hepatocyte. Magnification ×10 k.