Efficacy and Safety of Apatinib plus Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cancer: A Phase II Trial

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Parameter</td><td class="align_center"><svg height="8.8423pt" id="M19" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 11.0475 8.8423" width="11.0475pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M822 650H589L583 622C660 617 677 607 674 561C672 534 664 481 647 390L600 137H596L273 650H126L120 622C176 620 194 615 207 594C221 571 225 557 214 504L161 257C141 166 129 112 121 85C108 42 83 30 29 28L23 0H260L266 28C193 33 173 42 176 89C178 122 186 172 202 255L256 527H259L583 -8H612L690 390C708 481 720 535 728 558C744 603 756 619 816 622L822 650Z"></path></g></svg> (%)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Surgical method</td><td class="align_left"></td></tr><tr><td class="align_left">VATS McKeown radical esophagectomy under thoracoscope</td><td class="align_center">36 (94.8%)</td></tr><tr><td class="align_left">Radical resection of esophageal carcinoma with three incisions on the right side</td><td class="align_center">1 (2.6%)</td></tr><tr><td class="align_left">Esophageal carcinoma with two incisions on the left chest and neck</td><td class="align_center">1 (2.6%)</td></tr><tr><td class="align_left">Anastomotic leakage</td><td class="align_center">4 (10.5%)</td></tr><tr><td class="align_left">Wound infection rate</td><td class="align_center">3 (7.8%)</td></tr><tr><td class="align_left">Pulmonary infection rate</td><td class="align_center">7 (18.4%)</td></tr><tr><td class="align_left">The average bleeding amount in operation</td><td class="align_center"><span style="width: 85.8564ptpx;"><svg height="9.65783pt" id="M20" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -9.3079 85.8564 9.65783" width="85.8564pt" 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46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,44.33,0)"><path d="M285 378C315 398 338 416 353 432C373 451 384 474 384 503C384 579 325 635 236 635H235C182 635 136 610 108 579L65 516L85 496C110 533 150 575 205 575C258 575 300 543 300 481C300 407 232 369 141 339L147 310C163 315 188 321 211 321C268 321 338 284 338 192C338 94 288 40 217 40C160 40 119 68 93 91C85 98 77 97 69 91C60 84 47 71 46 58C44 46 48 35 62 22C75 10 116 -12 162 -12C234 -12 424 62 424 224C424 297 373 359 285 376V378Z"></path></g></svg> days</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Surgical-related complications.</div>

BioMed Research International

tab4

Table 4

Table 4: Efficacy and Safety of Apatinib plus Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cancer: A Phase II Trial 