High Expression of E2F4 Is an Adverse Prognostic Factor and Related to Immune Infiltration in Oral Squamous Cell Carcinoma

Figure 6

Correlation of E2F4 with tumor immune cell infiltration (TIMER and ssGSEA). (a–f) E2F4 expression levels were negatively and significantly correlated with the abundance of B cells, CD4⁺ T cells, CD8⁺ T cells, neutrophil, macrophage, and dendritic cells (Timer). (g) E2F4 expression levels were significantly and positively correlated with the abundance of Th2 cells, Tcm, and Tgd cells and negatively correlated with the abundance of NK CD56dim cells, CD8 T cells, DC, B cells, Treg, mast cells, pDC, iDC, TFH, cytotoxic cells, T cells, and Th17 cells (ssGSEA). ssGSEA: single-sample GSEA. -value < 0.05; value < 0.01; value < 0.001.

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