Sinomenine Inhibits Vasculogenic Mimicry and Migration of Breast Cancer Side Population Cells via Regulating miR-340-5p/SIAH2 Axis

<div>Sinomenine restrains malignant phenotype of breast cancer SP cells via the modulation of miR-340-5p/SIAH2 axis. Breast cancer SP cells transfected with miR-340-5p inhibitor or pcDNA3.1-SIAH2 were incubated with 0.75 mM of sinomenine under normoxia or hypoxia for 24 h. (a) Changes of vasculogenic mimicry formation were evaluated by tube formation assay and showed in the bar graph. (b) Changes of cell migration were determined by transwell assay and showed in the bar graph. 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BioMed Research International

fig4

Figure 4

Figure 4: Sinomenine Inhibits Vasculogenic Mimicry and Migration of Breast Cancer Side Population Cells via Regulating miR-340-5p/SIAH2 Axis 