The Molecular Mechanism of Traditional Chinese Medicine Prescription: Gu-tong Formula in Relieving Osteolytic Bone Destruction

Figure 2

Identification of the biological functions of compounds from GTF in the treatment of osteolytic metastasis. (a) Comprehensive functional characterization of the key compounds. (b) The protein-protein interaction (PPI) of GTF in the treatment of osteolytic metastasis. (c) The kernel of PPI. (d) Principal component analysis of the chemical space of GTF and compounds targeting IL6 and TGFB1. (e) The inhibitory effects of compounds in the GTF and compounds targeting IL6 and TGFB1 on the proliferation of tumor cell lines in public bioactivity databases.

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