A Novel Missense WFS1 Variant: Expanding the Mutational Spectrum Associated with Nonsyndromic Low-Frequency Sensorineural Hearing Loss

Figure 1

Pedigree of the 5-generation Chinese Han family and their audiological phenotypes. (a) Pedigree of the family affected with nonsyndromic hearing loss showing an autosomal dominant hereditary pattern. Males are denoted by squares, females by circles, and deceased by a diagonal line through the symbol. Proband: arrow; white symbol: normal hearing; black symbol: hearing impairment. (b) The pure-tone audiograms of some representative members in this family. Frequency in hertz (Hz) is plotted on the -axis and the auditory threshold in decibels (dB HL) on the -axis.

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