A Novel Missense WFS1 Variant: Expanding the Mutational Spectrum Associated with Nonsyndromic Low-Frequency Sensorineural Hearing Loss

Figure 4

The 3D protein structural modeling comparison of wild-type (WT) and mutant WFS1. (a) Molecular modeling of WT WFS1. The black dotted box indicates the position of amino acid residue 844 of WT WFS1. (b) Molecular modeling of mutant WFS1. Hydrogen bonds linking Ser844 with Glu824, Ser844 with Cys847, and Ser844 with Leu848 (yellow dotted lines) are shown.

(a)

(b)