Effects of CoQ10 Replacement Therapy on the Audiological Characteristics of Pediatric Patients with COQ6 Variants

Table 3

A comparison of the clinical variables of responders and nonresponders.

	Responders	Nonresponders	value	Methods
Number of patients	3	4	—	—
Sex (M : F)	1 : 2	3 : 1	0.486	Fisher’s exact test
Age at onset of SRNS (years)			0.629	Wilcoxon rank sum test
Age at onset of ESKD (years)			1.000	Wilcoxon rank sum test
Age at KT (years)			1.000	Wilcoxon rank sum test
Age at initiation of CoQ10 administration (years)			0.857	Wilcoxon rank sum test
Age at onset of SNHL (years)			0.800	Wilcoxon rank sum test
Average hearing threshold at time point of the initiation of oral CoQ10 administration (dB)			0.948	Wilcoxon rank sum test
Threshold shift (dB)			0.010	Wilcoxon rank sum test

These variables were compared by ears. M: male; F: female; R: right ear; L: left ear; SRNS: steroid-resistant nephrotic syndrome; ESKD: end-stage kidney disease; KT: kidney transplantation; SNHL: sensorineural hearing loss.