ESM1 Is a Promising Therapeutic Target and Prognostic Indicator for Esophageal Carcinogenesis/Esophageal Squamous Cell Carcinoma

Figure 3

PPI network, hub genes, functional enrichment analysis, and hub gene-pathway network. (a) The Venn diagram shows 144 DEGs that were commonly upregulated and downregulated between the two datasets. (b) Red and green represent upregulation and downregulation of the PPI network of the 144 DEGs, respectively. (c) Hub gene and related pathway network. Red, green, and pink represent upregulated, downregulated genes, and pathways, respectively. (d) ESM1 is a hub gene located in the top among the top 10 DEGs. (e, f) GO and KEGG presentation of 144 DEGs. The abscissa represents the larger enrichment ratio and the higher enrichment degree. Likewise, red represents a higher enrichment degree, and black represents a larger circle indicating a more enriched gene.

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