[Retracted] Exploration of ACE-Inhibiting Peptides Encrypted in Artemisia annua Using In Silico Approach

Table 5

In silico drug-likeness assessment illustrating the antihypertensive peptide ADMET profile.

	Physicochemical properties					Toxicity	Lipophilicity		Drug-likeness		Pharmacokinetics
	Mol. wt. (g/mol)	ROTB ()	HBA ()	HBD ()	ESOL log S	ToxinPred (SVM score)	TPSA (Å)	ClogPo/w	Bioavailability score	Lipinski filer	GIA	P-glycoprotein substrate	CYP3A4 inhibitor
Rule	<500	<10	<10	<5	—	—	<140	<5	—	—	—	—	—
AF	236.27	6	4	3	0.39 (HS)	Nontoxic -0.8	92.42	0.05	0.55	Yes (0)	High	No	No
FG	222.24	6	4	3	0.48 (HS)	Nontoxic -0.8	92.42	-0.16	0.55	Yes (0)	High	No	No
FP	262.3	5	4	3	-0.51 (VS)	Nontoxic -0.8	83.63	0.32	0.55	Yes (0)	High	No	No
FR	321.37	11	5	6	0.79 (HS)	Nontoxic -0.8	154.32	-0.66	0.55	Yes (1)	Low	No	No
FY	328.36	8	5	4	-0.66 (VS)	Nontoxic -0.8	112.65	0.83	0.55	Yes (0)	High	No	No
GW	261.28	6	4	4	0.23 (HS)	Nontoxic -0.8	108.21	-0.18	0.55	Yes (0)	High	No	No
LW	317.38	8	4	4	-0.18 (VS)	Nontoxic -0.79	108.21	1.09	0.55	Yes (0)	High	No	No
MW	335.42	9	4	4	-0.67 (VS)	Nontoxic -0.8	133.51	0.86	0.55	Yes (0)	High	Yes	No
RF	321.37	11	5	6	0.77 (HS)	Nontoxic -0.8	154.32	-0.59	0.55	Yes (1)	Low	No	No
RW	360.41	11	5	7	0.26 (HS)	Nontoxic -0.8	170.11	-0.44	0.55	Yes (1)	Low	No	No
WG	261.28	6	4	4	-0.11 (VS)	Nontoxic -0.8	108.21	0.08	0.55	Yes (0)	High	No	No
WL	317.38	8	4	4	-1.11 (VS)	Nontoxic -0.8	108.21	1.13	0.55	Yes (0)	High	Yes	No
YF	328.36	8	5	4	-0.66 (VS)	Nontoxic -0.8	112.65	0.78	0.55	Yes (0)	High	No	No
CF	268.33	7	4	3	0.32 (HS)	Nontoxic -0.79	131.22	-0.02	0.55	Yes (0)	High	No	No
GF	222.24	6	4	3	0.32 (HS)	Nontoxic -0.8	92.42	-0.23	0.55	Yes (0)	High	No	No
MF	296.39	9	4	3	-0.25 (VS)	Nontoxic -0.8	117.72	0.72	0.55	Yes (0)	High	No	No
Captopril	217.29	4	3	1	-1.14 (VS)		96.41	0.62	0.56	Yes (0)	High	No	No