Subcellular Proteome Analysis Reveals Apoptotic Vulnerability of T-Cell Acute Lymphoblastic Leukemia

Figure 4

Identification of a three-gene signature correlated with prognosis in acute leukemia. (a) Kaplan-Meier survival analysis of indicated protein and signature using GEPIA web server and TCGA mRNA datasets on AML. (b) Protein levels of mRNA transcriptions of indicated proteins from AML patients were compared. Red: tumors; grey: normal tissues. (c) Abundances of indicated proteins in various cancer patients were compared using the UALCAN web server and CPTAC mass spectrometry datasets. Red: tumors; blue: normal tissues. (d) A model to summarize the major proteomic alterations required for cells to develop resistance toward death receptor-mediated apoptosis.

(a)

(b)

(c)

(d)