Prognostic Nomogram for Gastrointestinal Stromal Tumors after Surgery Based on the SEER Database
Table 2
Univariate and multivariate Cox regression analyses of GSS from the constructed nomogram.
Variable
Univariate analysis
Multivariate analysis
HR
95% CI
value
HR
95% CI
value
Age at diagnosis (years)
1.020
1.010-1.030
<0.001
1.026
1.015-1.037
<0.001
Sex
Male
Female
0.824
0.640-1.060
0.132
Race
White
Black
1.350
0.993-1.850
0.055
1.518
1.096-2.102
0.012
Other
0.974
0.666-1.420
0.892
0.955
0.651-1.401
0.812
Tumor location
Stomach
Small intestine
1.630
1.230-2.160
<0.001
1.046
0.770-1.422
0.773
Colorectum
0.813
0.332-1.990
0.651
0.626
0.241-1.626
0.336
Other
3.900
2.700-5.630
<0.001
2.174
1.408-3.358
<0.001
Tumor grade
Well/moderately differentiated
Poorly differentiated/undifferentiated
4.570
3.230-6.460
<0.001
1.995
1.383-2.877
<0.001
Unknown
1.550
1.120-2.140
<0.001
1.143
0.815-1.603
0.437
Tumor size
≤2 cm
2-5 cm
1.930
0.803-4.660
0.142
1.662
0.683-4.045
0.263
5-10 cm
5.450
2.370-12.500
<0.001
2.732
1.142-6.537
0.024
>10 cm
11.400
5.020-25.800
<0.001
3.351
1.382-8.124
0.007
AJCC stage
I
II
2.950
1.720-5.060
<0.001
1.883
1.043-3.400
0.036
III
8.320
5.310-13.100
<0.001
4.088
2.339-7.142
<0.001
IV
12.800
8.090-20.200
<0.001
6.771
3.832-11.961
<0.001
Unknown
5.030
3.050-8.320
<0.001
2.849
1.547-5.248
0.001
Mitotic rate
≤5/5 mm2 HPF
>5/5 mm2 HPF
0.690
0.475-1.000
0.051
0.792
0.542-1.156
0.227
Unknown
1.400
1.060-1.850
0.018
1.006
0.696-1.453
0.976
Surgery
Local excision
Radical excision
1.680
1.070-2.640
0.023
1.103
0.681-1.784
0.691
Other
4.070
1.730-9.570
0.001
1.967
0.818-4.726
0.130
RNE
0
1-4
1.520
1.090-2.110
0.014
1.213
0.861-1.710
0.270
>4
1.350
0.969-1.890
0.076
0.928
0.658-1.310
0.671
Chemotherapy
No/unknown
Yes
2.000
1.540-2.590
<0.001
0.919
0.688-1.227
0.568
AJCC stage: American Joint Committee on Cancer stage; CI: confidence interval; gastrointestinal stromal tumors; GSS: cancer-specific survival for patients with GISTs; HR: hazard ratio.
