Fingolimod Nanoemulsions at Different Particle Sizes Define the Fate of Spinal Cord Injury Recovery

Figure 3

(a) Cell viability percentage of NSCs treated with nF60, nF190, and bulk FTY-720 at 10 ng/ml concentrations for 48 h. The control group showed significantly less NSC viability than the other groups. (b) LDH release from NSCs treated with nF60, nF190, and bulk FTY-720 at 10 ng/ml concentrations for 24 h. nF190 showed significantly less LDH release from NSCs than nF60. (c) BBB rating scale in the severe SCI model that received NF60, NF190, bulk fingolimod, and PBS (control) at days 1, 7, 14, 28, 35, and 42 postinjury by two blinded observers. NF190 showed a significantly higher functional recovery score than the other groups (, , and ). indicates , indicates , and indicates .

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