Fingolimod Nanoemulsions at Different Particle Sizes Define the Fate of Spinal Cord Injury Recovery

<div>(a) On the first day of regaining normal bladder function, SCI rats received nF60, nF190, free FTY-720, and PBS to the legion area. Normal bladder expression was restored in all animals within 10 days. nF190-treated rats were the first group to regain spontaneous bladder function. (b) The body weight of SCI rats was monitored 42 days postinjury. In the first week following SCI, all groups experienced considerable weight loss. Animals that received nF190 showed promoted body weight gain on day 42. (c) Soleus and gastrocnemius muscles were weighed in severe model SCI rats treated with nF60, nF190, free FTY-720, and PBS after perfusion. nF190 showed improved soleus muscle weight compared with free drug and control groups. 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BioMed Research International

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Figure 4

Figure 4: Fingolimod Nanoemulsions at Different Particle Sizes Define the Fate of Spinal Cord Injury Recovery 